| 2022 | Dan Winkler (st) |
| 2021 | Tyson Ross (st), DJ Peters (Aug 2 onward) |
| 2020 | Danny Santana |
| 2019 | Danny Santana (Apr 13 onwards) |
| 2018 | Doug Fister |
| 2017 | Steven Lerud (st), Pete Kozma (May 1 – Jul 19), Paolo Espino (Sep 1 onwards) |
| 2016 | Chris Gimenez (until May 3; minors), Lucas Harrell (Jul 29 onwards) |
| 2015 | Chris Gimenez |
| 2014 | Ron Washington (Manager) (until Sep 4, resigned) |
| 2013 | Ron Washington (Manager) |
| 2012 | Ron Washington (Manager) |
| 2011 | Ron Washington (Manager) |
| 2010 | Ron Washington (Manager) |
| 2009 | Ron Washington (Manager) |
| 2008 | Ron Washington (Manager) |
| 2007 | Eric Gagne (till Jul 31), Ron Washington (Aug 6 onwards, Manager) |
| 2006 | Kevin Walker (st), Edinson Volquez (Aug 7 onwards) |
| 2005 | Ryan Drese, Justin Thompson (Aug 16 onwards) |
| 2004 | Ryan Drese |
| 2003 | Aaron Fultz |
| 2002 | Aaron Myette |
| 2001 | Ryan Glynn |
| 2000 | Ryan Glynn |
| 1999 | Ruben Mateo (Jun 12th only – his ML debut), Ryan Glynn (Jun 13 onwards) |
| 1998 | |
| 1997 | |
| 1996 | |
| 1995 | Jackie Davidson (st replacement), Terry Burrows |
| 1994 | Terry Burrows |
| 1993 | Bob Patterson |
| 1992 | Terry Mathews |
| 1991 | Terry Mathews |
| 1990 | Craig McMurtry |
| 1989 | Craig McMurtry |
| 1988 | Craig McMurtry |
| 1987 | Ron Meridith |
| 1986 | Ron Meridith |
| 1985 | Ricky Wright |
| 1984 | Ricky Wright |
| 1983 | Ricky Wright |
| 1982 | Terry Bogener |
| 1981 | John Henry Johnson |
| 1980 | John Henry Johnson |
| 1979 | John Henry Johnson |
| 1978 | |
| 1977 | |
| 1976 | Tommy Boggs |
| 1975 | Tom Robson, Clyde Wright |
| 1974 | Tom Robson |
| 1973 | Rick Stelmaszek (Apr 17 – May 19) Bill Madlock |
| 1972 | |
Washington Senators Years |
|
| 1971 | Jeff Burroughs (st) |
| 1970 | Dave Nelson |
| 1969 | Bill Gogolewski (st) |
| 1968 | Tom Grieve (st) |
| 1967 | Jack Jenkins (st), Casey Cox, Dick Nold (Aug 19 – Sep 21), Buster Narum (Sep 20 – 26) |
| 1966 | Tim Cullen |
| 1965 | John Shew (st) |
| 1964 | |
| 1963 | Eddie Brinkman (st) |
| 1962 | Eddie Brinkman, Carl Bouldin (st, Apr 26, Jun 8-22, Sep 15-21) |
| 1961 | |
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